Symptom management

Symptomatic treatments can play a role in the management of pain and skeletal manifestations of Gaucher disease, even in patients receiving disease-specific therapy.1

Common symptomatic treatments are described below.

Pain

Patients who experience pain resulting from skeletal abnormalities may benefit from analgesic medications and oral corticosteroids.1,2

Skeletal manifestations

Skeletal manifestations such as fractures and osteonecrosis may necessitate surgical intervention in some patients. Joint replacement may be performed to restore mobility of the hips, knees or shoulders. The need for joint replacement in children needs to be carefully considered as it interferes with growth of the limbs.1

References

  1. 1.Baldellou A, Andria G, Campbell PE, et al. (2004) Paediatric non-neuronopathic Gaucher disease: recommendations for treatment and monitoring. Eur J Pediatr 163(2): 67-75.
  1. 2.Kaplan P, Baris H, De Meirleir L, et al. (2013) Revised recommendations for the management of Gaucher disease in children. Eur J Pediatr 172(4): 447-458.